An approach to classifying sequence tags sampled from Plasmodium falciparum var genes
نویسندگان
چکیده
منابع مشابه
Analysis of Plasmodium falciparum var genes expressed in children from Papua New Guinea.
BACKGROUND The variable antigen P. falciparum erythrocyte membrane protein-1 (PfEMP1) is a major virulence factor in malaria. A large number of var genes encode PfEMP1, and we hypothesized that a restricted PfEMP1 repertoire determines clinical disease presentation. We conducted a case-control study in Papua New Guinea and analyzed transcribed var genes in naturally infected children. METHODS...
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1% of the genes of the human malaria causing agent Plasmodium falciparum belong to the heterogeneous var gene family which encodes P. falciparum erythrocyte membrane protein 1 (PFEMP1). This protein mediates part of the pathogenesis of the disease by causing adherence of infected erythrocytes (IE) to the host endothelium. At any given time, only one copy of the family is expressed on the IE sur...
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enough that they might represent two portions of the same gene. Of the 215 protein-coding regions reported by Bowman et al., GlimmerM automatically finds 214 of them. (An earlier version of GlimmerM was provided to the annotators of chromosome 3.) The only gene missed is a short hypothetical protein (PFC0360w, 114 amino acids) with no homology to any known gene. Finally, given that chromosome 3...
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ژورنال
عنوان ژورنال: Molecular and Biochemical Parasitology
سال: 2007
ISSN: 0166-6851
DOI: 10.1016/j.molbiopara.2007.03.011